Thomas M. Disch has written the novels Camp Concentration (1968), 334 (1972), The Genocides (1965), The Puppies of Terra (1966), Echo Round His Bones (1967), Black Alice (with John Sladek, 1968), Clara Reeve (as "Leonie Hargrave," 1975), On Wings of Song (1979), Neighboring Lives (with Charles Naylor, 1981), The Businessman: A Tale of Terror (1984), The M.D.: A Horror Story (1991), The Priest: A Gothic Romance (1994), and The Substitute: a Study in Witchcraft (1999); short-story collections 102 H-Bombs (1967), Fun with Your New Head (1968), Getting into Death (1976), Fundamental Disch (1980), and The Man Who Had No Idea (1982); poetry collections The Right Way to Figure Plumbing (1972), ABCDEFG HIJKLMN POQRST UVWXYZ (1981), Burn This (1982), Orders of the Retina (1982), Here I Am, There You Are, Where Were We (1984), Yes, Let's: New and Selected Poems (1989), and Dark Verses and Light (1991); criticical volumes The Castle of Indolence: American Poetry Today (1995; a finalist for the National Book Critics Circle Award in Criticism), The Dreams Our Stuff Is Made Of: How Science Fiction Conquered the World (1998; Hugo and Locus Awards), and The Castle of Perseverance: Job Opportunities in Contemporary Poetry (2002). There are also the children's books The Brave Little Toaster (1986), The Tale of Dan de Lion (1986), The Brave Little Toaster Goes to Mars (1988), and A Child's Garden of Grammar (1997); and various other works including libretti.

Disch was the theater critic for The Nation from 1987 through 1992, and has later reviewed theater for the New York Daily News. His book reviews and critical essays have appeared in The Atlantic Monthy, Entertainment Weekly, Los Angeles Times Book Review, The Nation, New York Daily News, New York Post, New York Times Book Review, Parnassus, Playboy, Poetry, Times Literary Supplement (UK), Washington Post Book World, etc. He has served on the board of the National Book Critics Circle as Vice-President and Secretary.

He has taught at Wesleyan (Connecticut), the University of Minnesota, the Johns Hopkins Writing Seminars, and in 1996 he was Artist-in-Residence at the College of William and Mary.

In 1999 he received the Michael Braude Award from the American Academy of Arts and Letters.