Kathryn Cramer is an editor of the anthology connected with Neal Stephenson's Project Hieroglyph, forthcoming from HarperCollins in 2014 and in serial form before that, using Brainstem Media's PULP publishing platform. She is currently collaborating on a digital publishing project through her company Champlain Avenue with theater director and artist Edward Cornell.

She was the author of the pioneering hypertext short story "In Small & Large Pieces" (The Eastgate Quarterly Review of Hypertext, 1994), and had stories in Mathenauts (Rucker) and Asimov's. She has recently returned to writing fiction: her story "You, in Emulation" appeared in Nature in 2011, and her novelette "Am I Free to Go?" is forthcoming from Tor.com and will be produced as a dramatic audio book directed by Edward Cornell.

She won a World Fantasy Award for co-editing the anthology The Architecture of Fear (Arbor House, 1987) with Peter D. Pautz, and edited its World Fantasy finalist companion, Walls of Fear (William Morrow, 1990). She has co-edited with David G. Hartwell the last eleven volumes (numbers 7 through 17) of the Year's Best SF series from Eos (2002-2010) and Harper Voyager (2011-2012); numbers 9 through 11 were Locus Award finalists. From 2001 to 2009 they also edited a Year's Best Fantasy series. With Hartwell, she has edited seven further anthologies: Christmas Ghosts (Arbor House, 1987) and Spirits of Christmas (Wynwood / Tor, 1989); Masterpieces of Fantasy and Enchantment (SFBC, 1988) and Masterpieces of Fantasy and Wonder (SFBC, 1989); and three monumental retrospectives from Tor, The Ascent of Wonder: The Evolution of Hard SF (1994), The Hard SF Renaissance (2002), and The Space Opera Renaissance (2006); the first two were Locus Award finalists.

She was an editor of The New York Review of Science Fiction for most of its existence, for which she accumulated 17 Hugo semi-prozine nominations (1988-1991 and 1996-2008) and won a 1990 Readercon Award for Nonfiction Magazine. She was the P. Schuyler Miller Critic Guest of Honor at Confluence 2008 in Pittsburgh, PA.

For five years, she was a consultant with Wolfram Research; she worked on the data libraries for Mathematica 6, on the development of Wolfram Alpha, and on managing the company's social media presence and image, including creating the first prototypes of the Wolfram Research corporate blog. She currently consults with the antiquarian bookseller L. W. Currey where she keeps a large database healthy and translates book descriptions from the German.

She lives in Westport, New York, in the Adirondack Park, in a house with a bookstore in it overlooking Lake Champlain with her children, Peter and Elizabeth Hartwell. Since moving to the Adirondacks, she has become a painter and photographer, and her work appears in shows locally several times a year.